Thank you for your question about the distance between Louisville, Kentucky and Willoughby, Ohio.

A good resource for you to consult is Google Maps. You can access it here:

http://maps.google.com/

In your search query type in "Louisville, Kentucky to Willoughby, Ohio."

This will give you a map display of the driving route between the two locations and what directions to take. According to Google Maps, the distance is 421 miles and takes 5 hours and 47 minutes to drive there.

Please keep in mind that Google Maps is only an estimate and cannot account for sudden route changes like construction, traffic delays, weather, etc.

Hopefully this helps you out. Thank you again for your question!